Skip to main content

The BCG Lesson

ON JANUARY 2006, France became sole user of BCG vaccine Statens Serum Institut (SSI) for tuberculosis vaccination. Not long after, rapid increase in cases of adverse reactions (ADRs) came up; such as abscesses (in 73 percent of patients treated), around 30 percent had local reactions (lymphadenopathy of above one cm in size), while 20 patients developed suppurative lymphadenopathy.
 
Christelle Chol, leader of those who followed the patients for two years, found that the ADRs became consistent a year after their appearance or detection. They published their findings at the Pharmacoepidemiology and Drug Safety (Dec 5).
 
BCG vaccine—or Bacillus Calmette-Guerin (named after its discoverers)—contains weakened but alive strain of Mycobacterium bovis (a strain found in pigs). Because the bacteria can still stimulate reaction from a person’s immune system (without causing disease), it prepares the body to combat and destroy tuberculosis bacteria upon exposure. Studies in 1994 to 1995 showed a protective rate of 60 to 80 percent.
 
A clinical trial (1966) in the United States (Georgia and Alabama), however, showed only an efficacy of 14 percent. This figure left the authorities unconvinced in the use of BCG for mass vaccination there. Another trial (1979) in South India showed no efficacy at all.
 
And now we have these ADRs occurring in France. It might just be a case of contamination like what happened in 1930 (the first ever mass immunization using BCG also in France) where almost all of 240 infants immunized developed tuberculosis, resulting to 72 deaths. But this time, the French authorities believed that the ADRs came from the vaccine formulation itself.
 
The French problem is one of the many stories that highlight the dangers of synthetic medicines to health and life vis-à-vis their obvious accomplishments in chemotherapeutics. It tells of... [READ MORE]
 
This article appears in SunStar Cebu newspaper on 20 February 2013. 
Labels:

Comments

Post a Comment

Popular Posts

POST-PRESS: Narcissistic Disorder, Ground for Annulment

On 20 May 2011 (Friday), the First Division of the Philippine Court of Appeals dismissed the plea that Julie Balarbar, wife of 15 years of House Deputy Speaker Lorenzo Tañada III, filed questioning the November 25, 2010 decision of the Makati Regional Court declaring the marriage null and void on the ground that Balarbar had been diagnosed with narcissistic personality disorder (NPD). Pyschiatric evaluation show a diagnosis of NPD with anti-social features, from her involvement in a shoplifting incident, her closeness to and trips abroad with her male students, and a kissing incident with a co-professor. The Diagnostic and Statistical Manual of Mental Disorder Fourth Edition (DSM IV-TR) enumerated nine indicators of NPD, with only five of them needed for the diagnosis. It is not clear however which indicators have been found in the case of the Tañada annulment case. The Archdiocese of Manila also declared their canonical marriage void ab initio (void from the start) due to "gra
1 comment
Read more

Sex Industry Weathers Financial Crises

Varmus Christopher Forbes.com 12/29/08 14:00:05 GMT The sex industry traces back to 500 B.C., when traders from the Greek port of Miletus sold olisbos, an early version of the dildo. Today, the business of sex (including pornography) now runs into the tens of billions of dollars. (No official estimates are available; Wall Street analysts don't tend to track this stuff.) And while print and video sales are ebbing, as more free adult content has become available online, sales of un-reproducible sexual aids are still healthy. "Of course, there's concern about the economy, but right now our sales are growing," says Michael Trygstad, founder of Wet, a lubricant manufacturer in Van Nuys, Calif. "We've grown 30% this year alone. We've had to completely automate our factories to meet the tremendous demand. People are deciding to stay at home and engage in inexpensive entertainment.'' Slick marketing--and the ability to shop anonymously online--helps, too
5 comments
Read more

POST-PRESS: Filipinos Get Vitamin C from Vegetables

The DOST Food and Nutrition Research Institute (FNRI) recently issed a survey showing that 34 to 53 percent of Vitamin C consumed among Filipinos came from vegetables. Fruits merely contribute around 19 to 29 percent as a source. More than 50 percent of Vitamin C intake among adults, the elderly, and lactating women came from vegetables. Adolescent and pregnant women comprised 42.2 and 41.7 percent, respectively. Children have the lowest use of vegetables as Vitamin C source, contributing only 34.6 percent to diets among 6-12 agers and 17,2 percent among those ageing 6 months to 5-year olds. Vitamin C-rich vegetables include leafy greens like malunggay, ampalaya, petsay, saluyot, peppers (red and green), sitsaro and raw cabbage. Despite this figures, only 3 in every 10 households met the estimated average requirement (EAR) for Vitamin C, which is 80 percent of the recommended intake of the vitamin. And worse vegetable consumpion is on the downtrend over the years. It has decreased
Post a Comment
Read more